Acromegaly: What It Is, Causes, Symptoms, and Diagnosis

What is Acromegaly?

Acromegaly is a rare growth hormone disorder. It happens when the body makes too much growth hormone. This hormone comes from a small organ called the pituitary gland, which sits at the base of the brain. When there is too much growth hormone, bones and tissues grow more than normal. As a result, people with acromegaly may notice changes in their hands, feet, and face. Although acromegaly develops slowly, it can cause serious health problems if not treated. According to the World Health Organization, early detection helps prevent long-term issues.

Causes of Acromegaly

Most often, acromegaly is caused by a non-cancerous tumor in the pituitary gland. This tumor is called an adenoma. Because of the tumor, the gland makes too much growth hormone. In rare cases, tumors in other parts of the body can also cause acromegaly. These tumors may make growth hormone or another hormone that tells the pituitary gland to make more growth hormone. Either way, the result is the same: too much growth hormone in the body.

  • Pituitary gland tumor (adenoma)
  • Non-pituitary tumors (rare)
  • Family history (very rare)
  • However, most people with acromegaly do not have a family history of the condition.

    Symptoms of Acromegaly

    Acromegaly symptoms often develop slowly. Because of this, many people do not notice changes right away. Still, early signs of acromegaly can help with faster diagnosis. Common symptoms include:

  • Enlarged hands and feet
  • Changes in facial features (jaw, nose, lips)
  • Joint pain or swelling
  • Thickened skin
  • Deepened voice
  • Headaches
  • Vision problems
  • Excess sweating
  • Tiredness
  • Sometimes, people may also notice their rings or shoes no longer fit. In addition, acromegaly can cause health problems like high blood pressure, diabetes, or heart disease. Therefore, it is important to watch for these signs and talk to a doctor if you notice them.

    Diagnosis of Acromegaly

    Doctors use several steps when diagnosing acromegaly. First, they ask about symptoms and do a physical exam. Next, they may order blood tests to check growth hormone levels. If levels are high, doctors often do more tests to confirm the diagnosis. For example, an oral glucose tolerance test can help. In this test, you drink a sugary liquid, and doctors check if your growth hormone drops. In people with acromegaly, it usually stays high.

  • Blood tests for growth hormone and IGF-1
  • Oral glucose tolerance test
  • MRI scans to look for pituitary tumors
  • Vision tests if needed
  • Because acromegaly is rare, it can take time to diagnose. However, early diagnosis helps prevent serious health problems. The Centers for Disease Control and Prevention (CDC) recommends regular check-ups if you notice any symptoms.

    If you notice symptoms of acromegaly, consult a healthcare specialist for personalized advice.